1 April 2011 Visualization of light propagation in visible Chinese human head for functional near-infrared spectroscopy
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J. of Biomedical Optics, 16(4), 045001 (2011). doi:10.1117/1.3567085
Abstract
Using the visible Chinese human data set, which faithfully represents human anatomy, we visualize the light propagation in the head in detail based on Monte Carlo simulation. The simulation is verified to agree with published experimental results in terms of a differential path-length factor. The spatial sensitivity profile turns out to seem like a fat tropical fish with strong distortion along the folding cerebral surface. The sensitive brain region covers the gray matter and extends to the superficial white matter, leading to a large penetration depth (<3 cm). Finally, the optimal source-detector separation is suggested to be narrowed down to 3-3.5 cm, while the sensitivity of the detected signal to brain activation reaches the peak of 8%. These results indicate that the cerebral cortex folding geometry actually has substantial effects on light propagation, which should be necessarily considered for applications of functional near-infrared spectroscopy.
Ting Li, Hui Gong, Qingming Luo, "Visualization of light propagation in visible Chinese human head for functional near-infrared spectroscopy," Journal of Biomedical Optics 16(4), 045001 (1 April 2011). http://dx.doi.org/10.1117/1.3567085
Submission: Received ; Accepted
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KEYWORDS
Head

Brain

Signal detection

Cerebral cortex

Monte Carlo methods

Tissues

Visible radiation

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