1 April 2011 Dynamic fluorescence imaging for multiparametric measurement of tumor vasculature
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J. of Biomedical Optics, 16(4), 046008 (2011). doi:10.1117/1.3562956
Abstract
Angiogenesis is essential for tumor growth and a promising target for cancer therapy. Blood vessel monitoring is an indispensable tool for evaluation and development of anti-angiogenic drugs. Here, we report a new noninvasive in vivo imaging tool, named dynamic fluorescence imaging (DyFI), for the simultaneous measurement of multiple vascular parameters including vascular density, perfusion rate, and permeability using spatiotemporal profiles of indocyanine green. Using DyFI in a tumor xenograft model, we quantitatively measured multiple vascular parameters in tumors and normal tissues with high spatial resolution. The multimodality of this method allowed us to find negative spatial correlations between perfusion and permeability. Moreover, DyFI was effective for revealing the early effects of an anti-angiogenic drug. We suggest that DyFI could be a useful tool for the preclinical development of anti-angiogenic drugs.
Myunghwan Choi, Kyungsun Choi, Seung-Wook Ryu, Jungwhoi Lee, Chulhee Choi, "Dynamic fluorescence imaging for multiparametric measurement of tumor vasculature," Journal of Biomedical Optics 16(4), 046008 (1 April 2011). http://dx.doi.org/10.1117/1.3562956
Submission: Received ; Accepted
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KEYWORDS
Tumors

Luminescence

Tissues

Mathematical modeling

Imaging systems

In vivo imaging

Blood

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