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1 October 2011 Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina
Lin An, Tueng Shen, Ruikang K. Wang
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Journal of Biomedical Optics, Vol. 16, Issue 10, 106013 (October 2011). https://doi.org/10.1117/1.3642638
Abstract
This paper presents comprehensive and depth-resolved retinal microvasculature images within human retina achieved by a newly developed ultrahigh sensitive optical microangiography (UHS-OMAG) system. Due to its high flow sensitivity, UHS-OMAG is much more sensitive to tissue motion due to the involuntary movement of the human eye and head compared to the traditional OMAG system. To mitigate these motion artifacts on final imaging results, we propose a new phase compensation algorithm in which the traditional phase-compensation algorithm is repeatedly used to efficiently minimize the motion artifacts. Comparatively, this new algorithm demonstrates at least 8 to 25 times higher motion tolerability, critical for the UHS-OMAG system to achieve retinal microvasculature images with high quality. Furthermore, the new UHS-OMAG system employs a high speed line scan CMOS camera (240 kHz A-line scan rate) to capture 500 A-lines for one B-frame at a 400 Hz frame rate. With this system, we performed a series of in vivo experiments to visualize the retinal microvasculature in humans. Two featured imaging protocols are utilized. The first is of the low lateral resolution (16 μm) and a wide field of view (4 × 3 mm2 with single scan and 7 × 8 mm2 for multiple scans), while the second is of the high lateral resolution (5 μm) and a narrow field of view (1.5 × 1.2 mm2 with single scan). The great imaging performance delivered by our system suggests that UHS-OMAG can be a promising noninvasive alternative to the current clinical retinal microvasculature imaging techniques for the diagnosis of eye diseases with significant vascular involvement, such as diabetic retinopathy and age-related macular degeneration.
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2011/16(10)/106013/9/$25.00
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Lin An, Tueng Shen, and Ruikang K. Wang "Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina," Journal of Biomedical Optics 16(10), 106013 (1 October 2011). https://doi.org/10.1117/1.3642638
Published: 1 October 2011
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Cited by 92 scholarly publications and 7 patents.
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KEYWORDS
Imaging systems
Retina
Tissues
Phase compensation
Blood vessels
Image resolution
Visualization
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