Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography

Yuting Lin; David A. Thayer; Orhan Nalcioglu; Gultekin Gulsen

doi:10.1117/1.3643342

1 October 2011 Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography

Yuting Lin, David A. Thayer, Orhan Nalcioglu, Gultekin Gulsen

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Journal of Biomedical Optics, Vol. 16, Issue 10, 106015 (October 2011). https://doi.org/10.1117/1.3643342

Abstract

We present a magnetic resonance (MR)-guided near-infrared dynamic contrast enhanced diffuse optical tomography (DCE-DOT) system for characterization of tumors using an optical contrast agent (ICG) and a MR contrast agent [Gd-diethylenetriaminepentaacetic acid (DTPA)] in a rat model. Both ICG and Gd-DTPA are injected and monitored simultaneously using a combined MRI-DOT system, resulting in accurate co-registration between two imaging modalities. Fisher rats bearing R3230 breast tumor are imaged using this hybrid system. For the first time, enhancement kinetics of the exogenous contrast ICG is recovered from the DCE-DOT data using MR anatomical a priori information. As tumors grow, they undergo necrosis and the tissue transforms from viable to necrotic. The results show that the physiological changes between viable and necrotic tissue can be differentiated more accurately based on the ICG enhancement kinetics when MR anatomical information is utilized.

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Yuting Lin, David A. Thayer, Orhan Nalcioglu, and Gultekin Gulsen "Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography," Journal of Biomedical Optics 16(10), 106015 (1 October 2011). https://doi.org/10.1117/1.3643342

Published: 1 October 2011

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