Quantitative biomarkers of colonic dysplasia based on intrinsic second-harmonic generation signal

Shuangmu Zhuo; Xiaoqin Zhu; Jianxin Chen; Shusen Xie; Guizhu Wu

doi:10.1117/1.3659715

1 December 2011 Quantitative biomarkers of colonic dysplasia based on intrinsic second-harmonic generation signal

Shuangmu Zhuo, Xiaoqin Zhu, Jianxin Chen, Shusen Xie, Guizhu Wu

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 12, 120501 (December 2011). https://doi.org/10.1117/1.3659715

Abstract

Most colorectal cancers arise from dysplastic lesions, such as adenomatous polyps, and these lesions are difficult to be detected by the current endoscopic screening approaches. Here, we present the use of an intrinsic second-harmonic generation (SHG) signal as a novel means to differentiate between normal and dysplastic human colonic tissues. We find that the SHG signal can quantitatively identify collagen change associated with colonic dysplasia that is indiscernible by conventional pathologic techniques. By comparing normal with dysplastic mucosa, there were significant differences in collagen density and collagen fiber direction, providing substantial potential to become quantitative intrinsic biomarkers for in vivo clinical diagnosis of colonic dysplasia.

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Shuangmu Zhuo, Xiaoqin Zhu, Jianxin Chen, Shusen Xie, and Guizhu Wu "Quantitative biomarkers of colonic dysplasia based on intrinsic second-harmonic generation signal," Journal of Biomedical Optics 16(12), 120501 (1 December 2011). https://doi.org/10.1117/1.3659715

Published: 1 December 2011

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KEYWORDS

Second-harmonic generation

Collagen

Signal generators

Tissues

Endoscopy

Colorectal cancer

Error control coding

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