1 December 2011 Optical imaging of alpha emitters: simulations, phantom, and in vivo results
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There has been growing interest in investigating both the in vitro and in vivo detection of optical photons from a plethora of beta emitters using optical techniques. In this paper we have investigated an alpha particle induced fluorescence signal by using a commercial CCD-based small animal optical imaging system. The light emission of a 241Am source was simulated using GEANT4 and tested in different experimental conditions including the imaging of in vivo tissue. We believe that the results presented in this work can be useful to describe a possible mechanism for the in vivo detection of alpha emitters used for therapeutic purposes.
© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE)
Federico Boschi, Federico Boschi, Andrea Sbarbati, Andrea Sbarbati, Sergio Lo Meo, Sergio Lo Meo, Pier Luca Rossi, Pier Luca Rossi, Riccardo Calandrino, Riccardo Calandrino, Antonello E. Spinelli, Antonello E. Spinelli, } "Optical imaging of alpha emitters: simulations, phantom, and in vivo results," Journal of Biomedical Optics 16(12), 126011 (1 December 2011). https://doi.org/10.1117/1.3663441 . Submission:


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