1 February 2011 Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing
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Abstract
Nonlinear Raman microspectroscopy based on a broadband coherent anti-Stokes Raman scattering is an emerging technique for noninvasive, chemically specific, microscopic analysis of tissues and large population of cells and particles. The sensitivity of this imaging is a critical aspect of a number of the proposed biomedical application. It is shown that the incident laser power is the major parameter controlling this sensitivity. By careful optimizing the laser system, the high-quality vibrational spectra acquisition at the multi-kHz rate becomes feasible.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Rajan Arora, Georgi I. Petrov, Vladislav V. Yakovlev, Jian Liu, "Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing," Journal of Biomedical Optics 16(2), 021114 (1 February 2011). https://doi.org/10.1117/1.3533317 . Submission:
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