1 February 2011 Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing
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Abstract
Nonlinear Raman microspectroscopy based on a broadband coherent anti-Stokes Raman scattering is an emerging technique for noninvasive, chemically specific, microscopic analysis of tissues and large population of cells and particles. The sensitivity of this imaging is a critical aspect of a number of the proposed biomedical application. It is shown that the incident laser power is the major parameter controlling this sensitivity. By careful optimizing the laser system, the high-quality vibrational spectra acquisition at the multi-kHz rate becomes feasible.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Rajan Arora, Rajan Arora, Georgi I. Petrov, Georgi I. Petrov, Vladislav V. Yakovlev, Vladislav V. Yakovlev, Jian Liu, Jian Liu, } "Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing," Journal of Biomedical Optics 16(2), 021114 (1 February 2011). https://doi.org/10.1117/1.3533317 . Submission:
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