1 March 2011 Segmental analysis of indocyanine green pharmacokinetics for the reliable diagnosis of functional vascular insufficiency
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Abstract
Accurate and reliable diagnosis of functional insufficiency of peripheral vasculature is essential since Raynaud phenomenon (RP), most common form of peripheral vascular insufficiency, is commonly associated with systemic vascular disorders. We have previously demonstrated that dynamic imaging of near-infrared fluorophore indocyanine green (ICG) can be a noninvasive and sensitive tool to measure tissue perfusion. In the present study, we demonstrated that combined analysis of multiple parameters, especially onset time and modified Tmax which means the time from onset of ICG fluorescence to Tmax, can be used as a reliable diagnostic tool for RP. To validate the method, we performed the conventional thermographic analysis combined with cold challenge and rewarming along with ICG dynamic imaging and segmental analysis. A case-control analysis demonstrated that segmental pattern of ICG dynamics in both hands was significantly different between normal and RP case, suggesting the possibility of clinical application of this novel method for the convenient and reliable diagnosis of RP.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Yujung Kang, Jungsul Lee, Yuri An, Chulhee Choi, Jongwook Jeon, "Segmental analysis of indocyanine green pharmacokinetics for the reliable diagnosis of functional vascular insufficiency," Journal of Biomedical Optics 16(3), 030504 (1 March 2011). https://doi.org/10.1117/1.3556718 . Submission:
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