1 April 2011 Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation
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Abstract
Recently, it was shown in measurements carried out on humans that time-resolved near-infrared reflectometry and fluorescence spectroscopy may allow for discrimination of information originating directly from the brain avoiding influence of contaminating signals related to the perfusion of extracerebral tissues. We report on continuation of these studies, showing that the near-infrared light can be detected noninvasively on the surface of the tissue at large interoptode distance. A multichannel time-resolved optical monitoring system was constructed for measurements of diffuse reflectance in optically turbid medium at very large source-detector separation up to 9 cm. The instrument was applied during intravenous injection of indocyanine green and the distributions of times of flight of photons were successfully acquired showing inflow and washout of the dye in the tissue. Time courses of the statistical moments of distributions of times of flight of photons are presented and compared to the results obtained simultaneously at shorter source-detector separations (3, 4, and 5 cm). We show in a series of experiments carried out on physical phantom and healthy volunteers that the time-resolved data acquisition in combination with very large source-detector separation may allow one to improve depth selectivity of perfusion assessment in the brain.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Adam Liebert, Adam Liebert, Piotr Sawosz, Piotr Sawosz, Daniel Milej, Daniel Milej, Michal Kacprzak, Michal Kacprzak, Marcin Botwicz, Marcin Botwicz, Roman Maniewski, Roman Maniewski, Wojciech Weigl, Wojciech Weigl, Ewa Mayzner-Zawadzka, Ewa Mayzner-Zawadzka, Joanna Maczewska, Joanna Maczewska, Katarzyna Fronczewska, Katarzyna Fronczewska, Leszek Królicki, Leszek Królicki, } "Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation," Journal of Biomedical Optics 16(4), 046011 (1 April 2011). https://doi.org/10.1117/1.3574018 . Submission:
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