Confocal imaging reveals three-dimensional fine structure difference between ventral and dorsal nerve roots

Yuxiang Wu; Xiaohua Lv; Shaoqun Zeng; Tao Sui; Xiaojian Cao; Peng Sun

doi:10.1117/1.3575167

1 May 2011 Confocal imaging reveals three-dimensional fine structure difference between ventral and dorsal nerve roots

Yuxiang Wu, Xiaohua Lv, Shaoqun Zeng, Tao Sui, Xiaojian Cao, Peng Sun

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 5, 050502 (May 2011). https://doi.org/10.1117/1.3575167

Abstract

Peripheral nerve injury repair is one of the most challenging problems in neurosurgery, partially due to lack of knowledge of three-dimensional (3-D) fine structure and organization of peripheral nerves. In this paper, we explored the structures of nerve fibers in ventral and dorsal nerves with a laser scanning confocal microscopy. Thick tissue staining results suggested that nerve fibers have a different 3-D structure in ventral and dorsal nerves, and reconstruction from serial sectioning images showed that in ventral nerves the nerve fibers travel in a winding form, while in dorsal nerves, the nerve fibers form in a parallel cable pattern. These structural differences could help surgeons to differentiate ventral and dorsal nerves in peripheral nerve injury repair, and also facilitate scientists to get a deeper understanding about nerve fiber organization.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Yuxiang Wu, Xiaohua Lv, Shaoqun Zeng, Tao Sui, Xiaojian Cao, and Peng Sun "Confocal imaging reveals three-dimensional fine structure difference between ventral and dorsal nerve roots," Journal of Biomedical Optics 16(5), 050502 (1 May 2011). https://doi.org/10.1117/1.3575167

Published: 1 May 2011

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KEYWORDS

Nerve

Optical fibers

Confocal microscopy

3D image processing

Laser scanners

Injuries

3D image reconstruction

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