Semiautomated analysis of optical coherence tomography crystalline lens images under simulated accommodation

Eon Kim; Klaus Ehrmann; Jean-Marie Parel; Stephen Uhlhorn; David Borja; Esdras Arrieta-Quintero

doi:10.1117/1.3574613

1 May 2011 Semiautomated analysis of optical coherence tomography crystalline lens images under simulated accommodation

Eon Kim; Klaus Ehrmann; Jean-Marie Parel; Stephen Uhlhorn; David Borja; Esdras Arrieta-Quintero

Author Affiliations +

J. of Biomedical Optics, 16(5), 056003 (2011). https://doi.org/10.1117/1.3574613

Abstract

Presbyopia is an age related, gradual loss of accommodation, mainly due to changes in the crystalline lens. As part of research efforts to understand and cure this condition, ex vivo, cross-sectional optical coherence tomography images of crystalline lenses were obtained by using the Ex-Vivo Accommodation Simulator (EVAS II) instrument and analyzed to extract their physical and optical properties. Various filters and edge detection methods were applied to isolate the edge contour. An ellipse is fitted to the lens outline to obtain central reference point for transforming the pixel data into the analysis coordinate system. This allows for the fitting of a high order equation to obtain a mathematical description of the edge contour, which obeys constraints of continuity as well as zero to infinite surface slopes from apex to equator. Geometrical parameters of the lens were determined for the lens images captured at different accommodative states. Various curve fitting functions were developed to mathematically describe the anterior and posterior surfaces of the lens. Their differences were evaluated and their suitability for extracting optical performance of the lens was assessed. The robustness of these algorithms was tested by analyzing the same images repeated times.

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Eon Kim, Eon Kim, Klaus Ehrmann, Klaus Ehrmann, Jean-Marie Parel, Jean-Marie Parel, Stephen Uhlhorn, Stephen Uhlhorn, David Borja, David Borja, Esdras Arrieta-Quintero, Esdras Arrieta-Quintero, } "Semiautomated analysis of optical coherence tomography crystalline lens images under simulated accommodation," Journal of Biomedical Optics 16(5), 056003 (1 May 2011). https://doi.org/10.1117/1.3574613 . Submission:

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