1 May 2011 Real-time snapshot hyperspectral imaging endoscope
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Abstract
Hyperspectral imaging has tremendous potential to detect important molecular biomarkers of early cancer based on their unique spectral signatures. Several drawbacks have limited its use for in vivo screening applications: most notably the poor temporal and spatial resolution, high expense, and low optical throughput of existing hyperspectral imagers. We present the development of a new real-time hyperspectral endoscope (called the image mapping spectroscopy endoscope) based on an image mapping technique capable of addressing these challenges. The parallel high throughput nature of this technique enables the device to operate at frame rates of 5.2 frames per second while collecting a (x, y, λ) datacube of 350 × 350 × 48. We have successfully imaged tissue in vivo, resolving a vasculature pattern of the lower lip while simultaneously detecting oxy-hemoglobin.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Robert T. Kester, Noah Bedard, Liang S. Gao, Tomasz S. Tkaczyk, "Real-time snapshot hyperspectral imaging endoscope," Journal of Biomedical Optics 16(5), 056005 (1 May 2011). https://doi.org/10.1117/1.3574756 . Submission:
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