1 May 2011 Silver nanostructure sensing platform for maximum-contrast fluorescence cell imaging
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Abstract
We present herein a silver nanostructure-assisted sensing platform which consists of a combined structure of Ag nanowire (NW) and nanodot (ND) array. Highly enhanced fluorescence from fluorophore is attributed to a strongly coupled optical near-field interaction between proximately located Ag NW and NDs. We obtained enhanced fluorescence intensity with up to 140 folds, as contrasted from background intensity, reaching a theoretical maximum value. On the other hand, fluorescence lifetime was greatly reduced to 0.27 ns (from 2.17 ns for the same fluorophores without nanostructure). This novel platform can be a promising utility for optical imaging and labeling of biological systems with a great sensitivity.
Kyung-Min Lee, Arup Neogi, Purnima B. Neogi, Minjung Kim, Bongsoo Kim, Rafal Luchowski, Zygmunt K. Gryczynski, Nils Calander, Tae-Youl Choi, "Silver nanostructure sensing platform for maximum-contrast fluorescence cell imaging," Journal of Biomedical Optics 16(5), 056008 (1 May 2011). https://doi.org/10.1117/1.3579157
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