1 June 2011 In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury
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Abstract
For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Zhun Xu, Lihong V. Wang, Quing Zhu, "In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury," Journal of Biomedical Optics 16(6), 066020 (1 June 2011). https://doi.org/10.1117/1.3584847 . Submission:
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