1 June 2011 In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury
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Abstract
For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Zhun Xu, Zhun Xu, Lihong V. Wang, Lihong V. Wang, Quing Zhu, Quing Zhu, } "In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury," Journal of Biomedical Optics 16(6), 066020 (1 June 2011). https://doi.org/10.1117/1.3584847 . Submission:
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