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1 July 2011 Monte Carlo fluorescence microtomography
Alexander X. Cong, Wenxiang Cong, Ge Wang, Matthias C. Hofmann, Yong Xu
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Journal of Biomedical Optics, Vol. 16, Issue 7, 070501 (July 2011). https://doi.org/10.1117/1.3596171
Abstract
Fluorescence microscopy allows real-time monitoring of optical molecular probes for disease characterization, drug development, and tissue regeneration. However, when a biological sample is thicker than 1 mm, intense scattering of light would significantly degrade the spatial resolution of fluorescence microscopy. In this paper, we develop a fluorescence microtomography technique that utilizes the Monte Carlo method to image fluorescence reporters in thick biological samples. This approach is based on an l0-regularized tomography model and provides an excellent solution. Our studies on biomimetic tissue scaffolds have demonstrated that the proposed approach is capable of localizing and quantifying the distribution of optical molecular probe accurately and reliably.
©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Alexander X. Cong, Wenxiang Cong, Ge Wang, Matthias C. Hofmann, and Yong Xu "Monte Carlo fluorescence microtomography," Journal of Biomedical Optics 16(7), 070501 (1 July 2011). https://doi.org/10.1117/1.3596171
Published: 1 July 2011
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Cited by 6 scholarly publications.
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KEYWORDS
Luminescence
Monte Carlo methods
Tissue optics
Light scattering
Scattering
Microscopy
Spatial resolution
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