Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions

Thomas Dziekan; Carmen Weissbach; Jan Voigt; Bernd Ebert; Rainer Macdonald; Malte L. Bahner; Marianne Mahler; Michael Schirner; Michael Berliner; Birgitt Berliner; Jens Osel; Ilka Osel

doi:10.1117/1.3599958

1 July 2011 Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions

Thomas Dziekan, Carmen Weissbach, Jan Voigt, Bernd Ebert, Rainer Macdonald, Malte L. Bahner, Marianne Mahler, Michael Schirner, Michael Berliner, Birgitt Berliner, Jens Osel, Ilka Osel

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Journal of Biomedical Optics, Vol. 16, Issue 7, 076015 (July 2011). https://doi.org/10.1117/1.3599958

Abstract

Fluorescence imaging using the dye indocyanine green as a contrast agent was investigated in a prospective clinical study for the detection of rheumatoid arthritis. Normalized variances of correlated time series of fluorescence intensities describing the bolus kinetics of the contrast agent in certain regions of interest were analyzed to differentiate healthy from inflamed finger joints. These values are determined using a robust, parameter-free algorithm. We found that the normalized variance of correlation functions improves the differentiation between healthy joints of volunteers and joints with rheumatoid arthritis of patients by about 10% compared to, e.g., ratios of areas under the curves of raw data.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Thomas Dziekan, Carmen Weissbach, Jan Voigt, Bernd Ebert, Rainer Macdonald, Malte L. Bahner, Marianne Mahler, Michael Schirner, Michael Berliner, Birgitt Berliner, Jens Osel, and Ilka Osel "Detection of rheumatoid arthritis by evaluation of normalized variances of fluorescence time correlation functions," Journal of Biomedical Optics 16(7), 076015 (1 July 2011). https://doi.org/10.1117/1.3599958

Published: 1 July 2011

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