1 July 2011 Detection of localized inclusions of gold nanoparticles in Intralipid-1% by point-radiance spectroscopy
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Interstitial fiber-optic-based approaches used in both diagnostic and therapeutic applications rely on localized light-tissue interactions. We present an optical technique to identify spectrally and spatially specific exogenous chromophores in highly scattering turbid media. Point radiance spectroscopy is based on directional light collection at a single point with a side-firing fiber that can be rotated up to 360 deg. A side firing fiber accepts light within a well-defined, solid angle, thus potentially providing an improved spatial resolution. Measurements were performed using an 800-μm diameter isotropic spherical diffuser coupled to a halogen light source and a 600 μm, ∼43 deg cleaved fiber (i.e., radiance detector). The background liquid-based scattering phantom was fabricated using 1% Intralipid. Light was collected with 1 deg increments through 360 deg-segment. Gold nanoparticles , placed into a 3.5-mm diameter capillary tube were used as localized scatterers and absorbers introduced into the liquid phantom both on- and off-axis between source and detector. The localized optical inhomogeneity was detectable as an angular-resolved variation in the radiance polar plots. This technique is being investigated as a potential noninvasive optical modality for prostate cancer monitoring.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Serge Grabtchak, Serge Grabtchak, Tyler J. Palmer, Tyler J. Palmer, William M. Whelan, William M. Whelan, } "Detection of localized inclusions of gold nanoparticles in Intralipid-1% by point-radiance spectroscopy," Journal of Biomedical Optics 16(7), 077003 (1 July 2011). https://doi.org/10.1117/1.3597624 . Submission:

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