1 September 2011 Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants
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Abstract
Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO2) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO2 measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO2 measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO2 was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., ∼5% reproducibility for the NIRO 300. The novel StO2 values hence have a higher clinical relevance.
© (2011) Society of Photo-Optical Instrumentation Engineers (SPIE)
Carmen Jenny, Martin Biallas, Ivo Trajkovic, Jean-Claude Fauchere, Hans U. Bucher, Martin Wolf, "Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants," Journal of Biomedical Optics 16(9), 097004 (1 September 2011). https://doi.org/10.1117/1.3622756 . Submission:
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