4 October 2012 Optical phantoms with variable properties and geometries for diffuse and fluorescence optical spectroscopy
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Abstract
Growing interest in optical instruments for biomedical applications has increased the use of optically calibrated phantoms. Often associated with tissue modeling, phantoms allow the characterization of optical devices for clinical purposes. Fluorescent gel phantoms have been developed, mimicking optical properties of healthy and tumorous brain tissues. Specific geometries of dedicated molds offer multiple-layer phantoms with variable thicknesses and monolayer phantoms with cylindrical inclusions at various depths and diameters. Organic chromophores are added to allow fluorescence spectroscopy. These phantoms are designed to be used with 405 nm as the excitation wavelength. This wavelength is then adapted to excite large endogenous molecules. The benefits of these phantoms in understanding fluorescence tissue analysis are then demonstrated. In particular, detectability aspects as a function of geometrical and optical parameters are presented and discussed.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Barbara Leh, Rainer Siebert, Hussein Hamzeh, Laurent Ménard, Marie-Alix Duval, Yves Charon, Darine Abi-Haidar, "Optical phantoms with variable properties and geometries for diffuse and fluorescence optical spectroscopy," Journal of Biomedical Optics 17(10), 108001 (4 October 2012). https://doi.org/10.1117/1.JBO.17.10.108001 . Submission:
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