Photoacoustic detection of functional responses in the motor cortex of awake behaving monkey during forelimb movement

Janggun Jo; Hongyu Zhang; Paul Cheney; Xinmai Yang

doi:10.1117/1.JBO.17.11.110503

22 October 2012 Photoacoustic detection of functional responses in the motor cortex of awake behaving monkey during forelimb movement

Janggun Jo, Hongyu Zhang, Paul Cheney, Xinmai Yang

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 11, 110503 (October 2012). https://doi.org/10.1117/1.JBO.17.11.110503

Abstract

Photoacoustic (PA) imaging was applied to detect the neuronal activity in the motor cortex of an awake, behaving monkey during forelimb movement. An adult macaque monkey was trained to perform a reach-to-grasp task while PA images were acquired through a 30-mm diameter implanted cranial chamber. Increased PA signal amplitude results from an increase in regional blood volume and is interpreted as increased neuronal activity. Additionally, depth-resolved PA signals enabled the study of functional responses in deep cortical areas. The results demonstrate the feasibility of utilizing PA imaging for studies of functional activation of cerebral cortex in awake monkeys performing behavioral tasks.

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Janggun Jo, Hongyu Zhang, Paul Cheney, and Xinmai Yang "Photoacoustic detection of functional responses in the motor cortex of awake behaving monkey during forelimb movement," Journal of Biomedical Optics 17(11), 110503 (22 October 2012). https://doi.org/10.1117/1.JBO.17.11.110503

Published: 22 October 2012

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Cited by 14 scholarly publications and 1 patent.

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KEYWORDS

Brain

Signal detection

Neuroimaging

Photoacoustic spectroscopy

Magnetic resonance imaging

Sensors

Ultrasonography

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