Open Access
1 November 2012 Comparison of Schlemm's canal's biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical
Fei Wang, Guohua Shi, Xiqi Li, Jing Lu, Zhihua Ding, Xinghuai Sun, Chunhui Jiang, Yudong Zhang
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Abstract
Thirty-seven normal and primary open angle glaucoma (POAG) subjects were noninvasively imaged by a tailor-made real-time anterior segment swept source optical coherence tomography (SS-OCT) to demonstrate the differences of the Schlemm's canal (SC) between POAG and normal eyes. After the cross-section images of the anterior chamber angle were acquired by SS-OCT, SC was confirmed by two independent masked observers and the average area, long diameter, and perimeter of the SC were measured. In normal subjects the circumference, area, and long diameter is <b<508.34±87.81 μm</b<, <b<8023.89±1486.10  μm2</b<, and <b<272.83±49.39  μm</b<, respectively, and these parameters were <b<393.25±98.04  μm</b<, <b<3941.50±1210.69  μm2</b<, and <b<190.91±46.47 μm</b<  in the POAG subjects. The area of SC in the normal ones was significantly larger than that in POAG eyes (<b<p<0.001</b<), so as the long diameter and the perimeter (<b<p<0.001</b<; <b<p<0.001</b<).
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
Fei Wang, Guohua Shi, Xiqi Li, Jing Lu, Zhihua Ding, Xinghuai Sun, Chunhui Jiang, and Yudong Zhang "Comparison of Schlemm's canal's biological parameters in primary open-angle glaucoma and normal human eyes with swept source optical," Journal of Biomedical Optics 17(11), 116008 (1 November 2012). https://doi.org/10.1117/1.JBO.17.11.116008
Published: 1 November 2012
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Cited by 30 scholarly publications.
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KEYWORDS
Image segmentation

Optical coherence tomography

Eye

Biomedical optics

Adaptive optics

Control systems

Light sources

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