Temporal and spatial temperature distribution in the glabrous skin of rats induced by short-pulse CO2 laser

Pen-Li Lu; Shu-Shen Hsu; Meng-Li Tsai; Fu-Shan Jaw; An-Bang Wang; Chen-Tung Yen

doi:10.1117/1.JBO.17.11.117002

1 November 2012 Temporal and spatial temperature distribution in the glabrous skin of rats induced by short-pulse CO2 laser

Pen-Li Lu, Shu-Shen Hsu, Meng-Li Tsai, Fu-Shan Jaw, An-Bang Wang, Chen-Tung Yen

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Journal of Biomedical Optics, Vol. 17, Issue 11, 117002 (November 2012). https://doi.org/10.1117/1.JBO.17.11.117002

Abstract

Pain is a natural alarm that aids the body in avoiding potential danger and can also present as an important indicator in clinics. Infrared laser-evoked potentials can be used as an objective index to evaluate nociception. In animal studies, a short-pulse laser is crucial because it completes the stimulation before escape behavior. The objective of the present study was to obtain the temporal and spatial temperature distributions in the skin caused by the irradiation of a short-pulse laser. A fast speed infrared camera was used to measure the surface temperature caused by a CO2 laser of different durations (25 and 35 ms) and power. The measured results were subsequently implemented with a three-layer finite element model to predict the subsurface temperature. We found that stratum corneum was crucial in the modeling of fast temperature response, and escape behaviors correlated with predictions of temperature at subsurface. Results indicated that the onset latency and duration of activated nociceptors must be carefully considered when interpreting physiological responses evoked by infrared irradiation.

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Pen-Li Lu, Shu-Shen Hsu, Meng-Li Tsai, Fu-Shan Jaw, An-Bang Wang, and Chen-Tung Yen "Temporal and spatial temperature distribution in the glabrous skin of rats induced by short-pulse CO2 laser," Journal of Biomedical Optics 17(11), 117002 (1 November 2012). https://doi.org/10.1117/1.JBO.17.11.117002

Published: 1 November 2012

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