Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex

Zhen Wang; Weihua Luo; Fangyuan Zhou; Pengcheng Li; Qingming Luo

doi:10.1117/1.JBO.17.12.125001

3 December 2012 Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex

Zhen Wang, Weihua Luo, Fangyuan Zhou, Pengcheng Li, Qingming Luo

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Journal of Biomedical Optics, Vol. 17, Issue 12, 125001 (December 2012). https://doi.org/10.1117/1.JBO.17.12.125001

Abstract

Cerebral blood flow (CBF) is critical for the maintenance of cerebral function by guaranteed constant oxygen and glucose supply to brain. Collateral channels (CCs) are recruited to provide alternatives to CBF to ischemic regions once the primary vessel is occluded during ischemic stroke. However, the knowledge of the relationship between dynamic evolution of collateral flow and the distribution of regional blood flow remains limited. In this study, laser speckle imaging was used to assess dynamic changes of CCs and regional blood flow in a rat cortex with permanent middle cerebral artery occlusion (MCAo). We found that CCs immediately provided blood flow to ischemic territories after MCAo. More importantly, there were three kinds of dynamic changes of CCs during acute stroke: persistent CC, impermanent CC, and transient CC, respectively, related to different distributions of regional blood flow. Although there was the possible occurrence of peri-infarct depolarization (PID) during ischemia, there was no obvious significance about the onset time and duration of CCs between rats with and without PID. These results suggest that the initial arising of CCs does not ensure their persistence, and that collateral flow could be varied with distribution of regional blood flow in acute ischemic stroke, which may facilitate the understanding of collateral recruitment and promote the development of collateral therapeutics in the future.

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Zhen Wang, Weihua Luo, Fangyuan Zhou, Pengcheng Li, and Qingming Luo "Dynamic change of collateral flow varying with distribution of regional blood flow in acute ischemic rat cortex," Journal of Biomedical Optics 17(12), 125001 (3 December 2012). https://doi.org/10.1117/1.JBO.17.12.125001

Published: 3 December 2012

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