13 March 2012 Angiography with a multifunctional line scanning ophthalmoscope
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Abstract
A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal tracker (RT) and a photodynamic therapy laser treatment port. The mLSO was tested in a pilot clinical study on human subjects with and without retinal disease. The instrument exhibited robust retinal tracking and high-contrast line scanning imaging. The FA and ICGA angiograms showed a similar appearance of hyper- and hypo-pigmented disease features and a nearly equivalent resolution of fine capillaries compared to a commercial flood-illumination fundus imager. An mLSO-based platform will enable researchers and clinicians to image human and animal eyes with a variety of modalities and deliver therapeutic beams from a single automated interface. This approach has the potential to improve patient comfort and reduce imaging session times, allowing clinicians to better diagnose, plan, and conduct patient procedures with improved outcomes.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Daniel X. Hammer, R. Daniel Ferguson, Ankit H. Patel, Vanessa Vazquez, Deeba Husain, "Angiography with a multifunctional line scanning ophthalmoscope," Journal of Biomedical Optics 17(2), 026008 (13 March 2012). https://doi.org/10.1117/1.JBO.17.2.026008 . Submission:
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