Quantitative correlation between light depolarization and transport albedo of various porcine tissues

Sanaz Alali; Anthony Kim; Nasit Vurgun; Michael F. G. Wood; I. Alex Vitkin; Manzoor Ahmad

doi:10.1117/1.JBO.17.4.045004

11 April 2012 Quantitative correlation between light depolarization and transport albedo of various porcine tissues

Sanaz Alali, Anthony Kim, Nasit Vurgun, Michael F. G. Wood, I. Alex Vitkin, Manzoor Ahmad

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Journal of Biomedical Optics, Vol. 17, Issue 4, 045004 (April 2012). https://doi.org/10.1117/1.JBO.17.4.045004

Abstract

We present a quantitative study of depolarization in biological tissues and correlate it with measured optical properties (reduced scattering and absorption coefficients). Polarized light imaging was used to examine optically thick samples of both isotropic (liver, kidney cortex, and brain) and anisotropic (cardiac muscle, loin muscle, and tendon) pig tissues in transmission and reflection geometries. Depolarization (total, linear, and circular), as derived from polar decomposition of the measured tissue Mueller matrix, was shown to be related to the measured optical properties. We observed that depolarization increases with the transport albedo for isotropic and anisotropic tissues, independent of measurement geometry. For anisotropic tissues, depolarization was higher compared to isotropic tissues of similar transport albedo, indicating birefringence-caused depolarization effects. For tissues with large transport albedos (greater than ∼ 0.97), backscattering geometry was preferred over transmission due to its greater retention of light polarization; this was not the case for tissues with lower transport albedo. Preferential preservation of linearly polarized light over circularly polarized light was seen in all tissue types and all measurement geometries, implying the dominance of Rayleigh-like scattering. The tabulated polarization properties of different tissue types and their links to bulk optical properties should prove useful in future polarimetric tissue characterization and imaging studies.

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Sanaz Alali, Anthony Kim, Nasit Vurgun, Michael F. G. Wood, I. Alex Vitkin, and Manzoor Ahmad "Quantitative correlation between light depolarization and transport albedo of various porcine tissues," Journal of Biomedical Optics 17(4), 045004 (11 April 2012). https://doi.org/10.1117/1.JBO.17.4.045004

Published: 11 April 2012

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