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9 April 2012 Multifunctionality of indocyanine green-loaded biodegradable nanoparticles for enhanced optical imaging and hyperthermia intervention of cancer
Ronak H. Patel, Aniket S. Wadajkar, Nimit L. Patel, Venkaiah C. Kavuri, Kytai T. Nguyen, Hanli Liu
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Journal of Biomedical Optics, Vol. 17, Issue 4, 046003 (April 2012). https://doi.org/10.1117/1.JBO.17.4.046003
Abstract
The aim of this study was to develop and characterize multifunctional biodegradable and biocompatible poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with indocyanine green (ICG) as an optical-imaging contrast agent for cancer imaging and as a photothermal therapy agent for cancer treatment. PLGA-ICG nanoparticles (PIN) were synthesized with a particle diameter of 246±11  nm, a polydispersity index of 0.10±0.03, and ICG loading efficiency of 48.75±5.48%. PIN were optically characterized with peak excitation and emission at 765 and 810± 5  nm, a fluorescence lifetime of 0.30±0.01  ns, and peak absorbance at 780 nm. The cytocompatibility study of PIN showed 85% cell viability till 1-mg/ml concentration of PIN. Successful cellular uptake of ligand conjugated PIN by prostate cancer cells (PC3) was also obtained. Both phantom-based and in vitro cell culture results demonstrated that PIN (1) have the great potential to induce local hyperthermia (i.e., temperature increase of 8 to 10°C) in tissue within 5 mm both in radius and in depth; (2) result in improved optical stability, excellent biocompatibility with healthy cells, and a great targeting capability; (3) have the ability to serve as an image contrast agent for deep-tissue imaging in diffuse optical tomography.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Ronak H. Patel, Aniket S. Wadajkar, Nimit L. Patel, Venkaiah C. Kavuri, Kytai T. Nguyen, and Hanli Liu "Multifunctionality of indocyanine green-loaded biodegradable nanoparticles for enhanced optical imaging and hyperthermia intervention of cancer," Journal of Biomedical Optics 17(4), 046003 (9 April 2012). https://doi.org/10.1117/1.JBO.17.4.046003
Published: 9 April 2012
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Cited by 51 scholarly publications and 1 patent.
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KEYWORDS
Nanoparticles
Luminescence
Cancer
Magnesium
Absorbance
Optical spheres
Oncology
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