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5 April 2012 Accuracy of optical spectroscopy for the detection of cervical intraepithelial neoplasia without colposcopic tissue information; a step toward automation for low resource settings
Jose-Miguel Yamal, Getie A. Zewdie, Dennis D. Cox, Edward N. Atkinson, Scott B. Cantor, Calum E. MacAulay, Timon P. Buys, Kalatu Davies, Michele Follen, Isaac Adewole
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Journal of Biomedical Optics, Vol. 17, Issue 4, 047002 (April 2012). https://doi.org/10.1117/1.JBO.17.4.047002
Abstract
Optical spectroscopy has been proposed as an accurate and low-cost alternative for detection of cervical intraepithelial neoplasia. We previously published an algorithm using optical spectroscopy as an adjunct to colposcopy and found good accuracy (sensitivity = 1.00 [95% confidence interval (CI) = 0.92 to 1.00], specificity = 0.71 [95% CI = 0.62 to 0.79]). Those results used measurements taken by expert colposcopists as well as the colposcopy diagnosis. In this study, we trained and tested an algorithm for the detection of cervical intraepithelial neoplasia (i.e., identifying those patients who had histology reading CIN 2 or worse) that did not include the colposcopic diagnosis. Furthermore, we explored the interaction between spectroscopy and colposcopy, examining the importance of probe placement expertise. The colposcopic diagnosis-independent spectroscopy algorithm had a sensitivity of 0.98 (95% CI = 0.89 to 1.00) and a specificity of 0.62 (95% CI = 0.52 to 0.71). The difference in the partial area under the ROC curves between spectroscopy with and without the colposcopic diagnosis was statistically significant at the patient level (p = 0.05) but not the site level (p = 0.13). The results suggest that the device has high accuracy over a wide range of provider accuracy and hence could plausibly be implemented by providers with limited training.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Jose-Miguel Yamal, Getie A. Zewdie, Dennis D. Cox, Edward N. Atkinson, Scott B. Cantor, Calum E. MacAulay, Timon P. Buys, Kalatu Davies, Michele Follen, and Isaac Adewole "Accuracy of optical spectroscopy for the detection of cervical intraepithelial neoplasia without colposcopic tissue information; a step toward automation for low resource settings," Journal of Biomedical Optics 17(4), 047002 (5 April 2012). https://doi.org/10.1117/1.JBO.17.4.047002
Published: 5 April 2012
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KEYWORDS
Spectroscopy
Spectroscopes
Diagnostics
Cervical cancer
Cancer
Optical spectroscopy
Algorithm development
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