In vivo measurement of the shape of the tissue-refractive-index correlation function and its applicationto detection of colorectal field carcinogenesis

Andrew J. Gomes; Sarah K. Ruderman; Vadim Backman; Mart Dela Cruz; Ramesh K. Wali; Hemant K. Roy

doi:10.1117/1.JBO.17.4.047005

18 April 2012 In vivo measurement of the shape of the tissue-refractive-index correlation function and its applicationto detection of colorectal field carcinogenesis

Andrew J. Gomes, Sarah K. Ruderman, Vadim Backman, Mart Dela Cruz, Ramesh K. Wali, Hemant K. Roy

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Journal of Biomedical Optics, Vol. 17, Issue 4, 047005 (April 2012). https://doi.org/10.1117/1.JBO.17.4.047005

Abstract

Polarization-gated spectroscopy is an established method to depth-selectively interrogate the structural properties of biological tissue. We employ this method in vivo in the azoxymethane (AOM)-treated rat model to monitor the morphological changes that occur in the field of a tumor during early carcinogenesis. The results demonstrate a statistically significant change in the shape of the refractive-index correlation function for AOM-treated rats versus saline-treated controls. Since refractive index is linearly proportional to mass density, these refractive-index changes can be directly linked to alterations in the spatial distribution patterns of macromolecular density. Furthermore, we found that alterations in the shape of the refractive-index correlation function shape were an indicator of both present and future risk of tumor development. These results suggest that noninvasive measurement of the shape of the refractive-index correlation function could be a promising marker of early cancer development.

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Andrew J. Gomes, Sarah K. Ruderman, Vadim Backman, Mart Dela Cruz, Ramesh K. Wali, and Hemant K. Roy "In vivo measurement of the shape of the tissue-refractive-index correlation function and its applicationto detection of colorectal field carcinogenesis," Journal of Biomedical Optics 17(4), 047005 (18 April 2012). https://doi.org/10.1117/1.JBO.17.4.047005

Published: 18 April 2012

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