5 June 2012 In situ gold nanoparticles formation: contrast agent for dental optical coherence tomography
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In this work we demonstrate the potential use of gold nanoparticles as contrast agents for the optical coherence tomography (OCT) imaging technique in dentistry. Here, a new in situ photothermal reduction procedure was developed, producing spherical gold nanoparticles inside dentinal layers and tubules. Gold ions were dispersed in the primer of commercially available dental bonding systems. After the application and permeation in dentin by the modified adhesive systems, the dental bonding materials were photopolymerized concurrently with the formation of gold nanoparticles. The gold nanoparticles were visualized by scanning electron microscopy (SEM). The SEM images show the presence of gold nanospheres in the hybrid layer and dentinal tubules. The diameter of the gold nanoparticles was determined to be in the range of 40 to 120 nm. Optical coherence tomography images were obtained in two- and three-dimensions. The distribution of nanoparticles was analyzed and the extended depth of nanosphere production was determined. The results show that the OCT technique, using in situ formed gold nanoparticles as contrast enhancers, can be used to visualize dentin structures in a non-invasive and non-destructive way.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Ana Karla S. Braz, Ana Karla S. Braz, Renato E. de Araujo, Renato E. de Araujo, Tymish Y. Ohulchanskyy, Tymish Y. Ohulchanskyy, Shoba Shukla, Shoba Shukla, Earl J. Bergey, Earl J. Bergey, Anderson S. L. Gomes, Anderson S. L. Gomes, Paras N. Prasad, Paras N. Prasad, } "In situ gold nanoparticles formation: contrast agent for dental optical coherence tomography," Journal of Biomedical Optics 17(6), 066003 (5 June 2012). https://doi.org/10.1117/1.JBO.17.6.066003 . Submission: Received: 14 December 2011; Accepted: 4 April 2012
Received: 14 December 2011; Accepted: 4 April 2012; Published: 5 June 2012

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