4 June 2012 Quantitative analysis of the intraretinal layers and optic nerve head using ultra-high resolution optical coherence tomography
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Abstract
This study is designed to test the repeatability of the quantitative analysis of intraretinal layer thickness and cup-disc ratio of the optic nerve head using ultra-high resolution optical coherence tomography (UHR-OCT). Group A, containing 23 eyes of 12 healthy subjects, was imaged twice and group B, containing eight eyes of four subjects, was imaged three times. Intraretinal layers were segmented manually and the cup-to-disc ratio of the optic nerve head was analyzed. Custom-built automatic segmentation software was also used to segment a set of images for comparison. A total of nine intraretinal layers were visualized and extracted manually. With group A, the central foveal thickness was 186.4  ±  15.9  μm (mean  ±  SD). The average retinal thickness was 296.4  ±  21.3  μm. The best repeatability, obtained when two repeated scans were taken, was obtained for the outer nuclear layer followed by the ganglion cell layer, the inner nuclear layer, the retinal nerve fiber layer and the worst was obtained for the outer segment. The intraclass correlation ranged from 0.824 to 0.997. The coefficients of repeatability ranged from 3.24 to 18.3  μm, corresponding to 1.47% to 26.20%. With group B, high interclass correlations were found and the automatic segmentation results were compatible with the manual results. Our results indicated that more retinal features might be imageable using UHR-OCT.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yuhong Wang, Yuhong Wang, Hong Jiang, Hong Jiang, Meixiao Shen, Meixiao Shen, Byron L. Lam, Byron L. Lam, Delia Cabrera Cabrera DeBuc, Delia Cabrera Cabrera DeBuc, Yufeng Ye, Yufeng Ye, Ming Li, Ming Li, Aizhu Tao, Aizhu Tao, Yilei Shao, Yilei Shao, Jianhua Wang, Jianhua Wang, } "Quantitative analysis of the intraretinal layers and optic nerve head using ultra-high resolution optical coherence tomography," Journal of Biomedical Optics 17(6), 066013 (4 June 2012). https://doi.org/10.1117/1.JBO.17.6.066013 . Submission: Received: 8 October 2011; Accepted: 20 April 2012
Received: 8 October 2011; Accepted: 20 April 2012; Published: 4 June 2012
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