Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Chao Huang; Liming Nie; Robert W. Schoonover; Zijian Guo; Carsten O. Schirra; Mark A. Anastasio; Lihong V. Wang

doi:10.1117/1.JBO.17.6.066016

5 June 2012 Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Chao Huang, Liming Nie, Robert W. Schoonover, Zijian Guo, Carsten O. Schirra, Mark A. Anastasio, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 6, 066016 (June 2012). https://doi.org/10.1117/1.JBO.17.6.066016

Abstract

A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.

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Chao Huang, Liming Nie, Robert W. Schoonover, Zijian Guo, Carsten O. Schirra, Mark A. Anastasio, and Lihong V. Wang "Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data," Journal of Biomedical Optics 17(6), 066016 (5 June 2012). https://doi.org/10.1117/1.JBO.17.6.066016

Received: 14 January 2012; Accepted: 12 April 2012; Published: 5 June 2012

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KEYWORDS

Skull

Reconstruction algorithms

Acquisition tracking and pointing

Image restoration

Acoustics

X-ray computed tomography

X-rays

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