13 June 2012 Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging
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J. of Biomedical Optics, 17(6), 066022 (2012). doi:10.1117/1.JBO.17.6.066022
Abstract
The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Zthreshold.
Xiang Wen, Dan Zhu, Steven L. Jacques, Valery V. Tuchin, "Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging," Journal of Biomedical Optics 17(6), 066022 (13 June 2012). http://dx.doi.org/10.1117/1.JBO.17.6.066022
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KEYWORDS
Skin

Optical coherence tomography

Optical clearing

Reflectivity

Coherence imaging

In vivo imaging

Scattering

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