13 June 2012 Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging
Author Affiliations +
Abstract
The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Zthreshold.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Xiang Wen, Xiang Wen, Steven L. Jacques, Steven L. Jacques, Valery V. Tuchin, Valery V. Tuchin, Dan Zhu, Dan Zhu, } "Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging," Journal of Biomedical Optics 17(6), 066022 (13 June 2012). https://doi.org/10.1117/1.JBO.17.6.066022 . Submission: Received: 16 November 2011; Accepted: 17 April 2012
Received: 16 November 2011; Accepted: 17 April 2012; Published: 13 June 2012
JOURNAL ARTICLE
6 PAGES


SHARE
Back to Top