6 June 2012 Joint derivation method for determining optical properties based on steady-state spatially resolved diffuse reflectance measurement at small source-detector separations and large reduced albedo range: theory and simulation
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J. of Biomedical Optics, 17(6), 067004 (2012). doi:10.1117/1.JBO.17.6.067004
Abstract
Accurate determination of the optical properties (the absorption coefficient μa and the reduced scattering coefficient μs′) of tissues is very important in a variety of diagnostic and therapeutic procedures. Optical diffusion theory is frequently used as the forward model for describing the photon transfer in media with large reduced albedos (a′) and in large source-detector separations (SDS). Several other methods (PN approximation, hybrid diffusion-P3 approximation) have also been published that describe photon transfer in media with low a′ or small SDSs. We studied the theoretical models for the steady-state spatially resolved diffuse reflectance measurement to accurately determine μa and μs′ at large a′ range but small SDSs. Instead of using a single model, a joint derivation method is proposed. The developed method uses one of the best aforementioned theoretical methods separately in five ranges of a′ determined from several forward models. In the region of small SDSs (the range between 0.4 and 8 mm) and large a′ range (between 0.5 and 0.99), the best theoretical derivation model was determined. The results indicate that the joint derivation method can improve the derivation accuracy and that a′ range can be determined by the steady-state spatially resolved diffuse reflectance measurement.
Zhenzhi Shi, Ying Fan, Huijuan Zhao, Kexin Xu, "Joint derivation method for determining optical properties based on steady-state spatially resolved diffuse reflectance measurement at small source-detector separations and large reduced albedo range: theory and simulation," Journal of Biomedical Optics 17(6), 067004 (6 June 2012). http://dx.doi.org/10.1117/1.JBO.17.6.067004
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KEYWORDS
Optical properties

Diffuse reflectance spectroscopy

Scattering

Absorption

Tissues

Monte Carlo methods

Statistical modeling

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