11 June 2012 On-chip digital microfluidic architectures for enhanced actuation and sensing
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An on-chip system is presented with integrated architectures for digital microfluidic actuation and sensing. Localized actuation is brought about by a digital microfluidic multiplexer layout that overcomes the challenges of multi-microdrop interference, and complete two-dimensional motion is shown for microdrops on a 14×14 grid with minimized complexity by way of 14+14 inputs. At the same time, microdrop sensing is demonstrated in a folded-cavity design for enhanced optical intensity probing of internal fluid refractive indices. The heightened intensities from this on-chip refractometer are shown to have a linear response to the underlying fluid refractive index. An electro-dispensing technique is used to fabricate the folded-cavity optical architecture in a format that is tuned for the desired refractive index range and sensitivity. The overall lab-on-a-chip system is successful in integrating localized microdrop actuation and sensing.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Jacqueline A. Nichols, Christopher M. Collier, Emily L. Landry, Michael Wiltshire, Brandon Born, Jonathan F. Holzman, "On-chip digital microfluidic architectures for enhanced actuation and sensing," Journal of Biomedical Optics 17(6), 067005 (11 June 2012). https://doi.org/10.1117/1.JBO.17.6.067005 . Submission:


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