11 June 2012 On-chip digital microfluidic architectures for enhanced actuation and sensing
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Abstract
An on-chip system is presented with integrated architectures for digital microfluidic actuation and sensing. Localized actuation is brought about by a digital microfluidic multiplexer layout that overcomes the challenges of multi-microdrop interference, and complete two-dimensional motion is shown for microdrops on a 14×14 grid with minimized complexity by way of 14+14 inputs. At the same time, microdrop sensing is demonstrated in a folded-cavity design for enhanced optical intensity probing of internal fluid refractive indices. The heightened intensities from this on-chip refractometer are shown to have a linear response to the underlying fluid refractive index. An electro-dispensing technique is used to fabricate the folded-cavity optical architecture in a format that is tuned for the desired refractive index range and sensitivity. The overall lab-on-a-chip system is successful in integrating localized microdrop actuation and sensing.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Jacqueline A. Nichols, Jacqueline A. Nichols, Christopher M. Collier, Christopher M. Collier, Emily L. Landry, Emily L. Landry, Michael Wiltshire, Michael Wiltshire, Brandon Born, Brandon Born, Jonathan F. Holzman, Jonathan F. Holzman, } "On-chip digital microfluidic architectures for enhanced actuation and sensing," Journal of Biomedical Optics 17(6), 067005 (11 June 2012). https://doi.org/10.1117/1.JBO.17.6.067005 . Submission:
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