6 June 2012 New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm
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Abstract
To expand the optional laser wavelengths of photodynamic therapy (PDT) for port wine stain (PWS), the feasibility of applying a 457 nm laser to the PDT for infantile PWS was analyzed by mathematical simulation and was validated by clinical experiment. Singlet oxygen yield of 457 nm PDT or 532 nm PDT in an infantile PWS model and an adult PWS model was theoretically simulated. Fifteen PWS patients (14 infants and 1 adult) with 40 spots were treated with 457 nm (20 spots) and 532 nm (20 spots), respectively, in two PDT courses. Simulation results showed that under the same power density and irradiation time, singlet oxygen yield of 457 nm PDT and 532 nm PDT are similar in infantile PWS vessels. Yet, in adult PWS vessels, singlet oxygen yield of 457 nm PDT is lower than 532 nm PDT. Clinical outcomes showed that no statistic difference existed between 457 nm PDT and 532 nm PDT for infantile PWS. The result of this study suggested that 457 nm wavelength laser has the potential to be applied in PDT for infantile PWS.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Ying Wang, Zhaohui Zuo, Ying Gu, Naiyan Huang, Rong Chen, Buhong Li, Haixia Qiu, Jing Zeng, Jianguo Zhu, Jie Liang, "New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm," Journal of Biomedical Optics 17(6), 068003 (6 June 2012). https://doi.org/10.1117/1.JBO.17.6.068003 Submission: Received 6 February 2012; Accepted 27 April 2012
Submission: Received 6 February 2012; Accepted 27 April 2012
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