Diffuse optical imaging using spatially and temporally modulated light

Thomas D. O'Sullivan; Albert E. Cerussi; Bruce J. Tromberg; David J. Cuccia

doi:10.1117/1.JBO.17.7.071311

18 July 2012 Diffuse optical imaging using spatially and temporally modulated light

Thomas D. O'Sullivan, Albert E. Cerussi, Bruce J. Tromberg, David J. Cuccia

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Journal of Biomedical Optics, Vol. 17, Issue 7, 071311 (July 2012). https://doi.org/10.1117/1.JBO.17.7.071311

The authors describe the development of diffuse optical imaging (DOI) technologies, specifically the use of spatial and temporal modulation to control near infrared light propagation in thick tissues. We present theory and methods of DOI focusing on model-based techniques for quantitative, in vivo measurements of endogenous tissue absorption and scattering properties. We specifically emphasize the common conceptual framework of the scalar photon density wave for both temporal and spatial frequency-domain approaches. After presenting the history, theoretical foundation, and instrumentation related to these methods, we provide a brief review of clinical and preclinical applications from our research as well as our outlook on the future of DOI technology.

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Thomas D. O'Sullivan, Albert E. Cerussi, Bruce J. Tromberg, and David J. Cuccia "Diffuse optical imaging using spatially and temporally modulated light," Journal of Biomedical Optics 17(7), 071311 (18 July 2012). https://doi.org/10.1117/1.JBO.17.7.071311

Published: 18 July 2012

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