13 July 2012 Frequency domain multiplexing for speckle reduction in optical coherence tomography
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Quantitative analysis of optical coherence tomography data can be strongly hampered by speckle. Here, we introduce a new method to reduce speckle, which leverages from Fourier-domain configurations and operates on individual axial scans. By subdividing the digitized spectrum into a number of distinct narrower windows, each with a different center frequency, several independent speckle patterns result. These can be averaged to yield a lower-resolution image with strongly reduced speckle. The full resolution image remains available for human interpretation; the low resolution version can be used for parametric imaging or quantitative analysis. We demonstrate this technique using intravascular optical frequency domain imaging data acquired in vivo.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Gijs van Soest, Gijs van Soest, Evelyn Regar, Evelyn Regar, Antonius F. W. van der Steen, Antonius F. W. van der Steen, Martin L. Villiger, Martin L. Villiger, Guillermo J. Tearney, Guillermo J. Tearney, Brett E. Bouma, Brett E. Bouma, } "Frequency domain multiplexing for speckle reduction in optical coherence tomography," Journal of Biomedical Optics 17(7), 076018 (13 July 2012). https://doi.org/10.1117/1.JBO.17.7.076018 . Submission:

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