14 May 2012 Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy
Author Affiliations +
J. of Biomedical Optics, 17(8), 081406 (2012). doi:10.1117/1.JBO.17.8.081406
Abstract
We present near-infrared spectroscopy measurement of absolute cerebral hemoglobin concentration and saturation in a large sample of 36 healthy elderly (mean age, 85±6  years) and 19 young adults (mean age, 28±4  years). Non-invasive measurements were obtained on the forehead using a commercially available multi-distance frequency-domain system and analyzed using a diffusion theory model for a semi-infinite, homogeneous medium with semi-infinite boundary conditions. Our study included repeat measurements, taken five months apart, on 16 elderly volunteers that demonstrate intra-subject reproducibility of the absolute measurements with cross-correlation coefficients of 0.9 for absorption coefficient (μa), oxy-hemoglobin concentration ([HbO2]), and total hemoglobin concentration ([HbT]), 0.7 for deoxy-hemoglobin concentration ([Hb]), 0.8 for hemoglobin oxygen saturation (StO2), and 0.7 for reduced scattering coefficient (μ′s). We found significant differences between the two age groups. Compared to young subjects, elderly subjects had lower cerebral [HbO2], [Hb], [HbT], and StO2 by 10±4  μM, 4±3  μM, 14±5  μM, and 6%±5%, respectively. Our results demonstrate the reliability and robustness of multi-distance near-infrared spectroscopy measurements based on a homogeneous model in the human forehead on a large sample of human subjects. Absolute, non-invasive optical measurements on the brain, such as those presented here, can significantly advance the development of NIRS technology as a tool for monitoring resting/basal cerebral perfusion, hemodynamics, oxygenation, and metabolism.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Bertan Hallacoglu, Angelo Sassaroli, Sergio Fantini, Michael Wysocki, Elizabeth Guerrero-Berroa, Michal S. Beeri, Vahram Haroutunian, Merav Shaul, Irwin H. Rosenberg, Aron Troen, "Absolute measurement of cerebral optical coefficients, hemoglobin concentration and oxygen saturation in old and young adults with near-infrared spectroscopy," Journal of Biomedical Optics 17(8), 081406 (14 May 2012). https://doi.org/10.1117/1.JBO.17.8.081406
JOURNAL ARTICLE
9 PAGES


SHARE
RELATED CONTENT


Back to Top