Scattering anisotropy-weighted mesoscopic imaging

Zhengbin Xu; Ally-Khan Somani; Young L. Kim

doi:10.1117/1.JBO.17.9.090501

6 September 2012 Scattering anisotropy-weighted mesoscopic imaging

Zhengbin Xu, Ally-Khan Somani, Young L. Kim

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Journal of Biomedical Optics, Vol. 17, Issue 9, 090501 (September 2012). https://doi.org/10.1117/1.JBO.17.9.090501

Abstract

We report that when tissue images are formed via a small solid angle in the backward direction (i.e., back-directional gating), the image intensity is dominantly determined by tissue scattering anisotropy. Thus, this configuration allows for scattering anisotropy-weighted imaging that can provide an intrinsic contrast by capturing tissue structures and organizations. To demonstrate the immediate feasibility, we apply scattering anisotropy-weighted imaging to tissue blocks including basal-cell carcinomas as a pilot study. The main feature of our imaging approach is the high sensitivity to tumor locations and the simplicity for large-area visualization. We further envision that scattering anisotropy-weighted imaging could potentially be used to visualize tissue microenvironments in a mesoscopic (between microscopic and macroscopic) imaging setting.

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Zhengbin Xu, Ally-Khan Somani, and Young L. Kim "Scattering anisotropy-weighted mesoscopic imaging," Journal of Biomedical Optics 17(9), 090501 (6 September 2012). https://doi.org/10.1117/1.JBO.17.9.090501

Published: 6 September 2012

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