6 September 2012 Fluorescence spectra of blood and urine for cervical cancer detection
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Abstract
In the current study, the fluorescence emission spectra (FES) and Stokes shift spectra (SSS) of blood and urine samples of cervical cancer patients were obtained and compared to those of normal controls. Both spectra showed that the relative intensity of biomolecules such as porphyrin, collagen, Nicotinamide adenine dinucleotide, and flavin were quite out of proportion in cervical cancer patients. The biochemical mechanism for the elevation of these fluorophores is not yet definitive; nevertheless, these biomolecules could serve as tumor markers for diagnosis, screening, and follow-up of cervical cancers. To the best of our knowledge, this is the first report on FES and SSS of blood and urine of cervical cancer patients to give a sensitivity of 80% and specificity of 78%.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE)
Vadivel Masilamani, Vadivel Masilamani, Mohamad S. AlSalhi, Mohamad S. AlSalhi, Trinka Vijmasi, Trinka Vijmasi, Kanaganaj Govindarajan, Kanaganaj Govindarajan, Ram Rathan Rai, Ram Rathan Rai, Muhammad Atif, Muhammad Atif, Saradh Prasad, Saradh Prasad, Abdullah Aldwayyan, Abdullah Aldwayyan, } "Fluorescence spectra of blood and urine for cervical cancer detection," Journal of Biomedical Optics 17(9), 098001 (6 September 2012). https://doi.org/10.1117/1.JBO.17.9.098001 . Submission:
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