2 October 2013 Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications
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Abstract
A versatile, continuous wave, optical parametric oscillator is used in combination with photoacoustic spectroscopy for long-term trace gas experiments of volatile compounds emitted by biological samples. The optical parametric oscillator-based spectrometer (wavelength near 3 μm, 8-MHz linewidth, output power ∼1  W ) is successfully tested for the detection of hydrogen cyanide (HCN) emission from clover leaves, and Pseudomonas bacteria; in addition, the presence of HCN in exhaled human breath is measured. For specific experiments, the spectrometer is operated continuously up to 10 days and has a detection limit of 0.4 parts-per-billion volume of HCN in air over 10 s, using the P8 rotational line in the ν 3 vibrational band of HCN at 3287.25  cm −1 . This results in an overall sensitivity of the system of 2.5×10 −9   cm −1  Hz −1/2 .
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Denis D. Arslanov, Maria P. Castro, Noortje A. Creemers, Anne H. Neerincx, Marius Spunei, Julien Mandon, Simona M. Cristescu, Peter J. Merkus, Frans J. Harren, "Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications," Journal of Biomedical Optics 18(10), 107002 (2 October 2013). https://doi.org/10.1117/1.JBO.18.10.107002 . Submission:
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