22 October 2013 Determination of optical properties by interstitial white light spectroscopy using a custom fiber optic probe
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Abstract
We demonstrate interstitial recovery of absorption and scattering coefficients using a custom optical probe and a Monte Carlo (MC)–based recovery algorithm. The probe consists of six side-firing spectroscopy fibers contained in a 1.1-mm outer diameter cladding, with each fiber having a different axial and angular position on the probe. Broadband white light is delivered by one of the fibers and is detected steady-state by the remaining fibers. These spatially and spectrally resolved data are analyzed using a MC-based fitting algorithm in order to extract the local optical properties. The technique was verified in tissue-simulating phantoms consisting of Intralipid-20% as a scatterer and either manganese meso-tetra (4-sulfanatophenyl) porphine or intact human erythrocytes as an absorber. Absorption coefficients were recovered with a mean error of 9% and scattering coefficients were recovered with a mean error of 19%, whereas the hemoglobin oxygen saturation was recovered with a mean error of 12%. These results demonstrate the feasibility of optical property recovery for situations in which surface-contact spectroscopy is not a possibility, and where only a single probe can be inserted into the tissue.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Timothy M. Baran, Timothy M. Baran, Michael C. Fenn, Michael C. Fenn, Thomas H. Foster, Thomas H. Foster, } "Determination of optical properties by interstitial white light spectroscopy using a custom fiber optic probe," Journal of Biomedical Optics 18(10), 107007 (22 October 2013). https://doi.org/10.1117/1.JBO.18.10.107007 . Submission:
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