18 November 2013 Fast depth-sensitive fluorescence measurements in turbid media using cone shell configuration
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J. of Biomedical Optics, 18(11), 110503 (2013). doi:10.1117/1.JBO.18.11.110503
Depth-sensitive fluorescence spectroscopy in a two-layered epithelial tissue phantom was demonstrated using a cone shell configuration implemented by an axicon lens and a fiber assembly including five rings of collection fibers. Each collection fiber ring was located at a different radial distance away from the center, for which fluorescence measurements from all rings showed a larger range of sensitivities to the top and bottom layers compared to the previously reported cone shell configuration. Furthermore, multiple fluorescence spectra corresponding to a range of successive targeted depths can be obtained simultaneously, which shortened data acquisition dramatically and eliminated the mechanical moving components required for depth-sensitive optical measurements in the previous setup. This new setup therefore would be preferred in a clinical setting.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yi Hong Ong, Quan Liu, "Fast depth-sensitive fluorescence measurements in turbid media using cone shell configuration," Journal of Biomedical Optics 18(11), 110503 (18 November 2013). https://doi.org/10.1117/1.JBO.18.11.110503

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