15 July 2013 Transcutaneous delivery of micro- and nanoparticles with laser microporation
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J. of Biomedical Optics, 18(11), 111406 (2013). doi:10.1117/1.JBO.18.11.111406
Abstract
Fractional laser ablation is one of the relatively safe and minimally invasive methods used to administer micro- and nanoparticles into the skin at sufficiently large depth. In this article, we present the results of delivery of TiO 2 nanoparticles and Al 2 O 3 microparticles into skin. Fractional laser microablation of skin was provided by a system based on a pulsed Er:YAG laser with the following parameters: the wavelength 2940 nm, the pulse energy 3.0 J, and the pulse duration 20 ms. Ex vivo and in vivo human skin was used in the study. The suspensions of titanium dioxide and alumina powder in polyethylene glycol with particle size of about 100 nm and 27 μm, respectively, were used. In the ex vivo experiments, reflectance spectra of skin samples with administered particles were measured and histological sections of the samples were made. In the in vivo experiment, reflectance spectroscopy, optical coherence tomography, and clinical photography were used to monitor the skin status during one month after suspension administering. It is shown that particles can be delivered into dermis up to the depth 230 μm and distributed uniformly in the tissue. Spectral measurements confirm that the particles stay in the dermis longer than 1 month.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Elina A. Genina, Alexey N. Bashkatov, Leonid E. Dolotov, Galina N. Maslyakova, Vyacheslav I. Kochubey, Ilya V. Yaroslavsky, Gregory B. Altshuler, Valery V. Tuchin, "Transcutaneous delivery of micro- and nanoparticles with laser microporation," Journal of Biomedical Optics 18(11), 111406 (15 July 2013). http://dx.doi.org/10.1117/1.JBO.18.11.111406
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KEYWORDS
Skin

Particles

Nanoparticles

Aluminum

Optical coherence tomography

Reflectivity

Absorption

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