12 August 2013 Thermographic investigation of tumor size, and its correlation to tumor relative temperature, in mice with transplantable solid breast carcinoma
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Abstract
Treating cancer is one of the major challenges of modern medicine. Since mice models are an important tool in cancer treatment research, it is required to assess murine tumor development. Existing methods for investigating tumor development are either high cost and limited by their availability or suffer from low accuracy and reproducibility. In order to overcome these drawbacks, thermography may be used. DA3 breast cancer carcinoma tumors in 12  Balb/c mice were thermally imaged and monitored for a period of several weeks. Eight mice were treated with diffusing alpha emitters radiation therapy (DaRT) wires, while four were treated with inert wires. For large tumors, the area was estimated by analyzing thermal images and was found to be in correlation with manual caliper measurements. In addition, the correlation between tumor area and relative temperatures was calculated and compared to previous works. Temperature differences were larger for tumors treated with DaRT wires than tumors with inert wires. These correlations can be used to assist in tumor size estimation and reveal information regarding its metabolic state. Overall, thermography was shown to be a promising tool for assessing tumor development with the additional advantages of being nonradiative and potentially providing indication of intratumoral biological processes.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Michal Tepper, Michal Tepper, Asaf Shoval, Asaf Shoval, Oshrit Hoffer, Oshrit Hoffer, Hila Confino, Hila Confino, Michael Schmidt, Michael Schmidt, Itzhak Kelson, Itzhak Kelson, Yona Keisari, Yona Keisari, Israel Gannot, Israel Gannot, } "Thermographic investigation of tumor size, and its correlation to tumor relative temperature, in mice with transplantable solid breast carcinoma," Journal of Biomedical Optics 18(11), 111410 (12 August 2013). https://doi.org/10.1117/1.JBO.18.11.111410 . Submission:
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