We have presented an innovative laser-assisted reduction surgery (LARS) based on plasma-induced ablation and photodisruption effects. In addition, we developed a laser operation system. Fetuses of mice from the Institute for Cancer Research that were immersed in physiological saline were irradiated by convergent-pulsed laser with a wavelength of 1064 nm, pulse width of 6 ns, and pulse energy of 50 mJ. The hearts of the postirradiated fetuses were significantly damaged, which resulted in rapid fetal death. We also substantiated the safety of LARS by analyzing the heat distribution of the induced laser pulse with thermal distribution equations. The results demonstrate that this innovative method for pregnancy reduction is feasible.